Harry Spoelstra
I warned many time before for the cellular energy blackout that SarsCoV2 can cause! We now have the possible culprit: ORF7a 😬 #LongC0VIDphenotype 👇
Vipin M. Vashishtha
SARS-CoV-2 ORF7a: a mitochondrial saboteur! ➡️ A striking study shows that the viral accessory protein ORF7a hijacks host metabolism, impairing mitochondrial respiration, increasing ROS and disrupting glucose/lipid metabolism. It boosts PDK4, suppresses pyruvate oxidation—and, remarkably, also damages complex I and respiratory supercomplex assembly. 👉 The virus isn’t just using the cell’s machinery—it appears to be rewiring and destabilizing the mitochondria themselves. https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00833-8?uuid=uuid%3A3c33584f-dc1d-4143-8dad-3c3534eb4fd9
