Harry Spoelstra
Cardiovascular, Renal, and Pulmonary Risks of Long COVID: A Retrospective Cohort Study Stratified by Age and Sex 🚨“What Is New? • Clinically recognized Long COVID is associated with increased cardiovascular, renal, and pulmonary risks across adult age groups, with relatively larger risks observed in younger adults. • Sex‐specific differences are observed across multiple organ systems, indicating heterogeneity in postacute COVID‐19 risk profiles.” 😡REMINDER: I warned you already many times! ➡️Large TriNetX retrospective cohort (June 2020–Dec 2024), researchers analysed >2.6 million adults with documented COVID-19. After propensity-score matching for age, sex and major confounders, 315 612 individuals (157 806 with clinically coded LongC0VID via ICD-10 U09 vs matched recovered controls without the code) were evaluated for 15 new cardiovascular, renal and pulmonary (CRP) outcomes, stratified by age (18–50, 51–64, ≥65) and sex(Fig). ➡️LongC0VID: - Associated with higher absolute and relative risks for most outcomes (hypertension, atrial fibrillation, ischemic heart disease, heart failure, DVT, pulmonary embolism, ischemic stroke, CKD, pulmonary fibrosis, pulmonary hypertension, chronic bronchitis, chronic respiratory failure). - Relative risks were disproportionately elevated in younger adults(18-50y group), especially young women for cardiovascular/renal/thrombotic events and young men for pulmonary events (e.g., pulmonary fibrosis RR up to ~10). - Absolute risks rose with age in both groups. - Myocardial infarction and end-stage renal disease showed little consistent difference. - Results held in sensitivity analyses. - No mentions of reinfections or multiple infections appear in this paper. - Prior SARSCoV2 vaccination was not consistently associated with reduced CRP risk. ‼️So, clinically recognized LongC0VID markedly elevates long-term multi-organ (heart, kidney, lung) risks across all adult ages, with the highest relative burden falling on younger adults (18–50 years), supporting ongoing surveillance and risk-reduction strategies regardless of age or prior vaccination status. #AvoidSars2 #AvoidReinfections #PushForSurveillance https://www.ahajournals.org/doi/10.1161/JAHA.126.049226
