Harry Spoelstra
COVID-19 Vaccination and Risk of Post–COVID-19 Cardiovascular Disease: A Population-Based Cohort and Target Trial Emulation Study 🚨Interesting Australian, statewide Victorian linked-data cohort study of 2.4 million adults: Vaccination before or after infection associated with lower post-COVID MACE, with ~68% of that association not explained by prevented infection. ➡️Using time-varying Cox models, causal mediation analysis, and target-trial emulation, investigators tested whether vaccination before or after SARS-CoV-2 infection was associated with lower post-COVID cardiovascular disease. ➡️Findings: - Vaccination was associated with lower hazards of MACE and all secondary outcomes: stroke, heart failure, AMI, ACS, AF, and VTE. - Absolute risk reduction for MACE: 0.21% (pre-infection vaccination) and 0.24% (post-infection vaccination). - ≥3 doses showed a dose–response: progressively lower hazards across outcomes. - Mediation analysis: ~68% of the association with lower post-COVID CVD risk was not explained by prevention of SARSCoV2 infection. ➡️Reinfections, mentioned and modelled as a pathway, but this study report doesn’t dig into the standalone effect estimate for “how much extra CVD each reinfection adds.” ➡️Some classic well-noted limitations: Association ≠ proven biological CV protection. ➡️An earlier related analysis from the same Victorian programme (CSANZ ( 5 Aug)2026 abstract) reported an HR of 0.68 (0.66–0.71) for broader post-COVID CVD and treated both infection and reinfection as mediators. Most of the absolute-risk cut was attributed to a “direct” pathway rather than blocked first infection. http://x.com/HarrySpoelstra/status/2084979786548469996 ➡️In this large population, shots given before or after infection tracked with fewer later heart events, and most of that signal was not just “fewer infections.” That undercuts the simple story that vaccination’s only cardiovascular value is blocking COVID. It does not prove a direct vaccine-to-heart benefit. It does however suggest that the post-COVID heart-risk problem is not solved by infection-prevention alone! ‼️So, this report covers one of the largest population studies to split three things: when people were vaccinated (before vs after infection), how many doses they had, and how much of the lower CVD risk came from simply blocking infection. That matters now that most adults have already had COVID: it asks whether extra doses still track with fewer later heart events( → YES), not just milder acute illness(→ YES), and does vaccination change post-infection CV risk by any route other than preventing infection(→still ?)? #AvoidSars2 #AvoidReinfections https://academic.oup.com/ehjqcco/advance-article/doi/10.1093/ehjqcco/qcag139/8776131
Harry Spoelstra
Long-Term Protective Effects of COVID-19 Vaccination on Risk of Post-COVID Cardiovascular Disease. 🚨Interesting Australian paper🤔 "COVID-19 vaccination before or after SARSCoV-2 infection is associated with significant reductions in post-COVID CVD, preventing approximately
