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RTHM

RTHM

@rthm_health · Twitter · 2026-02-19 16:24 UTC

Description of the Study: The authors studied a prospective cohort of essential workers with paired plasma samples (one collected before the pandemic and one after) to test whether neurological Long COVID (N‑PASC) tracks with changes in Alzheimer’s-linked blood biomarkers. Participants with N‑PASC (n=227) were matched 1:1 to controls (n=227) who either had COVID without N‑PASC (n=124) or had no COVID by follow-up (n=103) N‑PASC required ≥1 neurological symptom (e.g., loss of taste/smell, brain fog, dizziness/vertigo, tinnitus, headache, balance issues) emerging within 3 months of infection and persisting more than 3 months. N‑PASC was assessed on average ~2.7 years after symptom onset. They measured neurological biomarkers well-established to correlate with neurodegeneration: pTau‑181, GFAP, NfL, Aβ40, Aβ42; plus derived measures like Aβ40/42 ratio and an inverse mean amyloid burden (IAB) metric. (Arrow pointing right) Small Citation
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